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By increasing NAD levels and activating the SIRT1 pathway, NNMTi inhibits the activation of inflammatory signaling pathways (such as the NFB pathway), thereby reducing macrophage infiltration and inflammatory factor release

[4] However, consistently taking large amounts of vitamins from multiple sources could potentially increase the risk of side effects (for example, very high vitamin B intake from multiple supplements over time can cause neuropathy, and high niacin from many sources could affect your liver)

But when inflammation is severe or chronic, it becomes excessive and damages the body its meant to protect.6 Unless you get it back under control, it can contribute to serious health complications down the line cardiovascular diseases, chronic obstructive pulmonary disease, cancer, and Alzheimers, to name a few.7 KPVs role as a treatment is to prevent those complications from arising or worsening